I've hit that lucky middle ground with meds where I've finally found one that seems to let me write as well as squashing the depression to manageable proportions. But it took a while, and a major crisis, to persuade me to try another drug.

I absolutely agree that SF should explore negative as well as positive scenarios. That's where the 'speculative' comes in! Problem is, I suspect that some of the examples of 'disability' in SF (or, to reflect original post, functional versus normal) are packaged with a host of assumptions, biases and the like. Anne McCaffrey's The Ship Who Sang ... Bujold's Falling Free ... hmm, maybe Justina Robson's novels are worth noting here: modified humans, humans with disorders and disabilities, cure-alls that don't ...

Am babbling! (which is ultra hard with a dysfunctional 'b' key)